Toxic Mechanisms of Five Heavy Metals: Mercury, Lead, Chromium, Cadmium, and Arsenic
Balali-Mood M, Naseri K, Tahergorabi Z, Khazdair MR, Sadeghi M
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- Year
- 2021
- Journal
- Frontiers in Pharmacology
- WikiBiome key
balali-mood-2021-toxic-mechanisms-five-heavy-metals
Synthesizes the carcinogenic and neurotoxic mechanisms of mercury, lead, chromium, cadmium, and arsenic, emphasizing how each metal generates ROS and triggers oxidative-stress-dependent dysbiosis. WikiBiome depends on this comprehensive toxicology to connect multi-metal environmental exposures to the cross-condition dysbiotic signatures observed in neurodegenerative, metabolic, and cancer-associated signatures.
Criteria met: 2 · 3 · 4Used in 24 visible records
metalArsenic→metalCadmium→metalChromium→diseaseDepression→diseaseGastric Cancer→metalLead→metalMercury→metalNickel→mechanismBiomarkers→mechanismBlood-Brain Barrier→mechanismChelation Therapy→mechanismCOX-2 (Cyclooxygenase-2)→mechanismDevelopmental Metal Vulnerability: Critical Windows of Susceptibility→mechanismDietary Arsenic Exposure→mechanismDietary Cadmium Exposure→mechanismDietary Lead Exposure→mechanismThe Exposome→mechanismFerroptosis→defenseGlutathione (GSH)→mechanismHeavy Metal Neurotoxicity→mechanismHeavy Metals→mechanismIL-1beta (Interleukin-1 Beta)→defenseMetal-Driven Inflammation→mechanismInterleukin-6 (IL-6)→Connect the evidence
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