Heavy Metals Exposure and Alzheimer's Disease and Related Dementias
Bakulski KM, Seo YA, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK
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Citation record
- Year
- 2020
- Journal
- Journal of Alzheimer's Disease
- WikiBiome key
bakulski-2020-heavy-metals-alzheimers-dementias
Why this source matters
Synthesizes epidemiological evidence linking lead (lifetime cumulative exposure), mercury (organic and inorganic forms), cadmium, and arsenic to Alzheimer's disease and related dementias through multiple pathways: direct neurotoxicity, calcium channel disruption, and epigenetic silencing. Critical for WikiBiome because it establishes metal exposure assessment methodology (bone lead vs. blood lead, biomarker selection) essential for accurate metallomics phenotyping across neurodegenerative disease signatures.
Criteria met: 2 · 3 · 4Used in 12 visible records
diseaseAlzheimer's Disease→metalCadmium→metalCalcium→metalLead→metalManganese→metalMercury→diseaseParkinson's Disease→mechanismAmyloid-Beta→mechanismNeurodegeneration and Metals→mechanismTau Phosphorylation→stopSTOP: Iron Supplementation for Alzheimer's Disease→analysisMetal-Disease Matrix: A Cross-Source Synthesis→