WikiBiomeThe human microbiome encyclopedia
WikiBiome/Evidence source
Keystone evidence record

Heavy Metals Exposure and Alzheimer's Disease and Related Dementias

Bakulski KM, Seo YA, Hickman RC, Brandt D, Vadari HS, Hu H, Park SK

Share & cite
Article toolsHeavy Metals Exposure and Alzheimer's Disease and Related Dementias

Links open in a new tab.

Citation record

Year
2020
Journal
Journal of Alzheimer's Disease
WikiBiome key
bakulski-2020-heavy-metals-alzheimers-dementias
Why this source matters

Synthesizes epidemiological evidence linking lead (lifetime cumulative exposure), mercury (organic and inorganic forms), cadmium, and arsenic to Alzheimer's disease and related dementias through multiple pathways: direct neurotoxicity, calcium channel disruption, and epigenetic silencing. Critical for WikiBiome because it establishes metal exposure assessment methodology (bone lead vs. blood lead, biomarker selection) essential for accurate metallomics phenotyping across neurodegenerative disease signatures.

Criteria met: 2 · 3 · 4

Used in 12 visible records

diseaseAlzheimer's Disease→metalCadmium→metalCalcium→metalLead→metalManganese→metalMercury→diseaseParkinson's Disease→mechanismAmyloid-Beta→mechanismNeurodegeneration and Metals→mechanismTau Phosphorylation→stopSTOP: Iron Supplementation for Alzheimer's Disease→analysisMetal-Disease Matrix: A Cross-Source Synthesis→
Author connection

Are you an author of this work?

Every coauthor may independently claim authorship through ORCID, check this record, add context, and see where the work is used.

Claim or review this work →
Researcher discussion

Connect the evidence

Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.

0 posts

No discussion yet. Start with a precise question or a source-backed observation.

Transparent record

Published page changes

This record shows only material changes published on this page, including changes to its content, evidence, conclusions, or author context. Internal processes and discussion activity are excluded. Pending, declined, and withdrawn proposals remain private.

0 changes

No material page changes have been recorded yet.