Mechanisms7 sources
Th17/Treg Balance
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Search: “Treg”
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Mechanisms3 sources
Butyrate
The most biologically potent short-chain fatty acid (C4). Butyrate is the primary energy source for colonocytes, a histone deacetylase (HDAC) inhibitor with broad epigenetic effects, and a key anti-inflammatory mediator. Its depletion -- driven by loss of butyrate-produ…
Mechanisms5 sources
IL-10 (Interleukin-10)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms9 sources
Immune Balance
The immune system is not a monolith but a dynamic equilibrium between pro-inflammatory effector responses (Th1, Th2, Th17) and anti-inflammatory regulatory responses (Treg, IL-10, TGF-beta). Metals and the microbiome are two of the most potent environmental modulators o…
Mechanisms9 sources
Short-Chain Fatty Acids (SCFAs)
The most extensively referenced missing concept in this wiki. SCFAs -- acetate (C2), propionate (C3), and butyrate (C4) -- are the primary metabolic products of anaerobic bacterial fermentation of dietary fiber in the colon. They serve as the critical molecular link bet…
Mechanisms6 sources
TGF-beta (Transforming Growth Factor Beta)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms5 sources
Vitamin D
This knowledge-base record is being expanded from WikiBiome’s evidence graph.