Mechanisms6 sources
Gingipains
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Search: “gingipain”
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6 records in this view
Mechanisms10 sources
Functional Shielding
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms4 sources
IL-8 (Interleukin-8 / CXCL8)
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Diseases7 sources
Periodontitis
Periodontitis is a chronic inflammatory disease of the periodontal tissues (gingiva, periodontal ligament, alveolar bone) driven by a dysbiotic polymicrobial biofilm in the subgingival pocket. The keystone pathogen is porphyromonas gingivalis, whose zinc-dependent gingi…
Microorganisms6 sources
Porphyromonas
A Gram-negative, obligate anaerobic genus with the keystone pathogen P. gingivalis at its center. Named for its porphyrin (heme) requirement, Porphyromonas is the prototypical periodontal pathogen and one of the most important organisms connecting oral health to systemi…
Microorganisms15 sources
Porphyromonas gingivalis
A Gram-negative obligate anaerobe and keystone pathogen of the oral microbiome that causes chronic periodontitis and is increasingly implicated in systemic diseases including alzheimers disease and cardiovascular disease. P. gingivalis virulence is fundamentally depende…