WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to defense.
Inflammation is a broad concept, but in the metallomics context it has a specific character: heavy metals and pathogens activate overlapping inflammatory pathways, creating convergent pathology where distinguishing the metal contribution from the microbial contribution …
A heterodimer of S100A8 and S100A9 calcium-binding proteins that constitutes approximately 60% of the cytosolic protein content of neutrophils. Calprotectin is a central effector of nutritional immunity, sequestering essential transition metals from invading pathogens a…
The primary intracellular iron storage protein, capable of sequestering up to 4,500 iron atoms in a single molecule as a mineralized ferric oxyhydroxide core. Ferritin is one of the most elegant solutions evolution has produced for the iron paradox: iron is essential fo…
The master regulator of systemic iron homeostasis. Hepcidin is a 25-amino-acid peptide hormone produced primarily by hepatocytes that controls iron absorption, recycling, and distribution by binding to and degrading ferroportin (SLC40A1/FPN) -- the only known cellular i…
An iron-binding glycoprotein of the transferrin family that sequesters iron (and potentially other metals) from pathogens at mucosal surfaces and sites of inflammation. Lactoferrin is a key effector of nutritional immunity, complementing calprotectin's role in metal res…
The biological processes by which organisms maintain proper intracellular and systemic concentrations of essential metals -- importing what is needed, storing excess safely, and exporting or sequestering surplus. Both host and microbial systems have evolved elaborate me…
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