Metal Dyshomeostasis as a Driver of Gut Pathology in Autism Spectrum Disorders
O'Grady K, Grabrucker AM
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- Year
- 2025
- Journal
- Journal of Neurochemistry
- WikiBiome key
ogrady-2025-metal-dyshomeostasis-asd
PRISMA systematic review showing that toxic metals (Hg, Cd, Pb) and zinc deficiency produce **overlapping gut pathologies**—barrier dysfunction, permeability, inflammation, dysbiosis—establishing a unifying mechanism: metals reduce zinc bioavailability through protein-binding competition, mimicking zinc deficiency. WikiBiome depends on this evidence to connect metal dysregulation to zinc depletion across multiple conditions and to explain why metal burden and zinc loss appear as paired signatures in disease.
Criteria met: 2 · 3 · 4Used in 15 visible records
diseaseAutism Spectrum Disorder→metalLead→metalMercury→metalNickel→metalZinc→mechanismDevelopmental Metal Vulnerability: Critical Windows of Susceptibility→mechanismEDTA→mechanismGut-Brain Axis→mechanismGut-Metal-Microbiome Interactions→mechanismMaternal Immune Activation→mechanismMis-Metallation→mechanismOxidative Stress→interventionChelation Therapy→interventionGluten-Free Diet→analysisMetal-Disease Matrix: A Cross-Source Synthesis→Connect the evidence
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