Kravchenko 2023 — Thyroid hormones and minerals in immunocorrection of disorders in autoimmune thyroid diseases
Kravchenko V, Zakharchenko T
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- Year
- 2023
- Journal
- Frontiers in Endocrinology
- WikiBiome key
kravchenko-2023-thyroid-hormones-minerals-aitd
Maps mineral-specific immunomodulation in autoimmune thyroid disease, showing how selenium supplementation reduces TPO antibodies via selenoprotein GPx upregulation, zinc enables thymulin activation for T cell function, and iron deficiency impairs TPO activity while increasing autoimmune susceptibility. WikiBiome depends on this evidence to establish how dysbiotic organisms (depleted in metal-dependent SCFA producers) directly undermine thyroid barrier tolerance — linking metal dysbiosis to Treg dysfunction via metal-dependent enzyme failures.
Criteria met: 2 · 3 · 4Used in 16 visible records
metalCalcium→diseaseGraves' Disease→metalIodine→metalIron→metalMagnesium→metalSelenium→mechanismImmune Balance→defenseMetal-Driven Inflammation→mechanismN-Glycosylation→mechanismNF-kB Signaling Pathway→mechanismOxidative Stress→mechanismThyroid Autoimmunity→stopSTOP: Iodine Supplementation for Graves' Disease→stopSTOP: Iodine Supplementation for Hashimoto's Thyroiditis→stopSTOP: Iron Supplementation for Graves' Disease→analysisMetal-Disease Matrix: A Cross-Source Synthesis→Connect the evidence
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