Metals in the pathogenesis of type 2 diabetes
Abdul Rehman Khan, Fazli Rabbi Awan
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Citation record
- Year
- 2014
- Journal
- Journal of Diabetes and Metabolic Disorders
- WikiBiome key
khan-2014-metals-type2-diabetes
Why this source matters
Establishes that type 2 diabetes is characterized by zinc depletion (via urinary loss and ZnT8 transporter dysfunction) and iron overload (elevated ferritin driving insulin resistance), while toxic metals (lead, nickel, cadmium, arsenic) directly impair insulin signaling and glucose metabolism. WikiBiome depends on this evidence to explain why metal-dysregulated microbiota (depleted in zinc-dependent bacteria) cannot restore insulin sensitivity—linking nutritional immunity failure to dysbiotic metabolic incompetence.
Criteria met: 2 · 3 · 4Used in 13 visible records
metalChromium→diseaseChronic Kidney Disease→metalCopper→metalIron→metalMagnesium→metalManganese→metalNickel→diseaseType 2 Diabetes→metalZinc→mechanismInsulin Resistance→stopSTOP: Iron Supplementation for Type 2 Diabetes-Associated Anemia→stopSTOP: Iron Supplementation for PCOS→analysisMetal-Disease Matrix: A Cross-Source Synthesis→