Role of Cadmium and Nickel in Estrogen Receptor Signaling and Breast Cancer: Metalloestrogens or Not?
Aquino NB, Sevigny MB, Sabangan J, Louie MC
Share & cite
Links open in a new tab.
Citation record
- Year
- 2012
- Journal
- Journal of Environmental Science and Health Part C - Environmental Carcinogenesis and Ecotoxicology Reviews
- WikiBiome key
aquino-2012-cadmium-nickel-metalloestrogens
Establishes cadmium and nickel as metalloestrogens with distinct mechanistic signatures: cadmium binds ERα with affinity near estradiol, activating classical estrogen target genes; nickel induces histone deacetylation and tumor suppressor methylation without competing for estradiol binding. WikiBiome depends on this evidence to explain how metal burden drives estrogen-dependent dysbiosis (estrobolome expansion) in endometriosis and hormonally-sensitive cancers—linking metallomics to the estrobolome pathway.
Criteria met: 2 · 3 · 4Used in 16 visible records
diseaseBreast Cancer→metalCadmium→diseaseEndometriosis→diseaseFemale Infertility→metalNickel→diseasePolycystic Ovary Syndrome→mechanismAcidic Microenvironment→mechanismAromatase→mechanismEndocrine Disruption→mechanismMetalloestrogen→mechanismMetalloestrogens→mechanismMis-Metallation→stopSTOP: Calcium Supplementation with Cadmium Exposure→stopSTOP: Iron Supplementation for PCOS→stopSTOP: Standard (Unselected) Probiotics for Endometriosis→analysisMetal-Disease Matrix: A Cross-Source Synthesis→Connect the evidence
Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.
No discussion yet. Start with a precise question or a source-backed observation.
Published page changes
This record shows only material changes published on this page, including changes to its content, evidence, conclusions, or author context. Internal processes and discussion activity are excluded. Pending, declined, and withdrawn proposals remain private.
No material page changes have been recorded yet.