WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to microbe.
The leading bacterial cause of diarrheal disease worldwide, with an estimated 400-500 million cases annually. C. jejuni is notable in the metallomics context for possessing a nickel-dependent [NiFe] hydrogenase essential for colonization but lacking urease -- a striking…
Enterobacter is a genus of Gram-negative, facultatively anaerobic bacteria in the enterobacteriaceae family. Key species include enterobacter cloacae (the most clinically relevant) and E. hormaechei. Like other Enterobacteriaceae, Enterobacter possesses iron-dependent s…
A Gram-negative bacterium that spans the commensal-pathogen spectrum, with pathogenic variants (UPEC, STEC, EHEC) deploying nickel-dependent enzymes as virulence factors. E. coli is the model organism for nickel transport biology -- the NikABCDE system was first charact…
A gastric pathogen that is arguably the most nickel-dependent human pathogen known. Two of its key virulence factors — urease and [NiFe] hydrogenase — require nickel, and the bacterium has evolved an elaborate nickel trafficking, storage, and regulation system to suppor…
The causative agent of tuberculosis (TB), the leading infectious disease killer worldwide (~1.3 million deaths annually). M. tuberculosis has an exceptionally complex metal biology: it deploys nickel-dependent hydrogenase and urease for intracellular survival, species-s…
A Gram-negative enteric pathogen that possesses four distinct [NiFe] hydrogenases -- the most of any well-characterized human pathogen. These hydrogenases are critical for intracellular survival within macrophages, and a triple hydrogenase mutant is 100% avirulent in mo…
A Gram-negative intracellular pathogen causing bacillary dysentery (shigellosis), responsible for approximately 165 million illness episodes and over 1 million deaths annually, predominantly in children under 5 in developing countries. S. flexneri relies on nickel-depen…