WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to metal.
The most abundant mineral in the human body, with ~99% stored in bones and teeth. Calcium's biological significance extends far beyond structural support -- it is the universal second messenger in cell signaling, controlling neurotransmitter release, muscle contraction,…
An essential trace element with a striking dual nature: required for survival as a cofactor for critical enzymes (SOD1, cytochrome c oxidase, ceruloplasmin), yet toxic in excess through Fenton-like redox cycling and mis metallation of iron-sulfur clusters. Copper is ele…
Manganese is an essential trace element with a narrow therapeutic window: required as a cofactor for critical enzymes including Mn-SOD (SOD2), pyruvate carboxylase, arginase, and ribonucleotide reductase, yet profoundly neurotoxic at elevated levels martin 2022 manganes…
Zinc is the most widely utilized transition metal cofactor in biology. Approximately 9-10% of the eukaryotic proteome and 5-6% of the bacterial proteome consists of zinc-binding proteins capdevila 2024 bacterial metallostasis sensing trafficking. An estimated one-third …