Ruminococcaceae

Why Ruminococcaceae Depletion Matters#

Ruminococcaceae depletion is among the most consistent microbiome findings across disease states—paralleling and overlapping with Lachnospiraceae depletion.

Schizophrenia: Ruminococcaceae depletion correlates with negative symptoms and poorer functioning; FEP patients show the most pronounced loss.^{[1]Alterations of the Gut Microbiota in Patients with SchizophreniaLi Z, Tao X, Wang D et al. · 2024Open reference 1 ↓[2]Theleritis 2024 -- Association of gut dysbiosis with first-episode psychosis (Review)Christos Theleritis, Maria-Ioanna Stefanou, Marina Demetriou et al. · 2024Open reference 2 ↓}

MS: Depleted in MS patients; diet-responsive (Mediterranean diet enriches Ruminococcaceae).^{[3]Feeding the gut microbiome: impact on multiple sclerosisMatteo Bronzini, Alessandro Maglione, Rachele Rosso et al. · 2023Open reference 3 ↓} IBD, PD, CRC, obesity: Consistently depleted across inflammatory and neurodegenerative conditions.

Diet-responsive: Fiber-rich and Mediterranean diets selectively enrich Ruminococcaceae.^{[4]The interplay between diet and the gut microbiome: implications for health and diseaseFiona C. Ross, Dhrati Patangia, Ghjuvan Grimaud et al. · 2024Open reference 4 ↓[5]Latorre-Pérez 2021 — The Spanish Gut Microbiome Reveals Links Between Microorganisms and Mediterranean DietAdriel Latorre-Pérez, Marta Hernández, Jose Ramón Iglesias et al. · 2021Open reference 5 ↓}