Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis
Liu L, Chen J, Liu C, Liu Y, Luo J, Chen J, Fu Y, Xu Y, Wu H, Li X, Wang H
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- Year
- 2022
- Journal
- Frontiers in Nutrition
- WikiBiome key
liu-2022-heavy-metals-breast-cancer-meta-analysis
Meta-analytic confirmation that copper, cadmium, and lead are elevated while zinc and manganese are depleted in breast cancer patients across 36 case-control studies. Anchors the metallomic layer of the breast cancer signature and supports the cross-condition pattern in which Cd-driven estrogen mimicry and Cu/Zn dyshomeostasis recur across estrogen-sensitive conditions.
Criteria met: 2 · 3 · 4Used in 11 visible records
diseaseBreast Cancer→metalCadmium→metalChromium→metalCopper→metalLead→metalManganese→metalNickel→metalZinc→mechanismEpithelial-Mesenchymal Transition→mechanismMetalloestrogens→analysisMetal-Disease Matrix: A Cross-Source Synthesis→Connect the evidence
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