Heavy metals in the diet: unraveling the molecular pathways linked to neurodegenerative disease risk
Guevara-Ramirez P, Tamayo-Trujillo R, Cadena-Ullauri S, Ruiz-Pozo V, Paz-Cruz E, Annunziata G, Verde L, Frias-Toral E, Simancas-Racines D, Zambrano AK
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- Year
- 2024
- Journal
- Food and Agricultural Immunology
- WikiBiome key
guevara-ramirez-2024-dietary-heavy-metals-neurodegeneration
Links dietary metal exposure (mercury, cadmium, lead, arsenic in foods) to neurodegenerative disease mechanisms through metal-specific pathways: mercury disrupts glutamate transport, cadmium blocks calcium channels, arsenic dysregulates dopamine, chromium generates ROS, lead crosses the BBB. WikiBiome depends on this evidence to explain how food-borne metal burden—not environmental exposure alone—drives proteinopathy and why dietary interventions (phytochemicals, chelation) can interrupt metal-driven neurodegeneration.
Criteria met: 1 · 2 · 4Used in 11 visible records
diseaseAlzheimer's Disease→metalChromium→diseaseDepression→metalLead→metalMercury→metalNickel→mechanismBlood-Brain Barrier→mechanismEDTA→mechanismHeavy Metals→mechanismMitochondrial Dysfunction→mechanismNeurodegeneration and Metals→Connect the evidence
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