WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Metal sensing is the set of regulatory mechanisms bacteria use to detect intracellular metal concentrations and adjust gene expression accordingly. Because metal ions cannot be synthesized or degraded -- only imported, exported, sequestered, or trafficked -- sensing and…
Protein-based transcription factors that sense intracellular metal concentrations and regulate gene expression accordingly. Metalloregulators are the decision-making layer of bacterial metal homeostasis -- they read the labile metal pool, determine whether a specific me…
Mis-metallation is the displacement of the correct metal cofactor from an enzyme or protein by a wrong metal ion, leading to loss of function, gain of aberrant function, or structural disruption. This is one of the most fundamental and pervasive mechanisms of metal toxi…