Mechanisms5 sources
Gene Regulation
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Mechanisms8 sources
Metal Sensing
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Mechanisms3 sources
Metalloregulator
Protein-based transcription factors that sense intracellular metal concentrations and regulate gene expression accordingly. Metalloregulators are the decision-making layer of bacterial metal homeostasis -- they read the labile metal pool, determine whether a specific me…
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Mechanisms4 sources
Nickel Transporters
Specialized membrane proteins that import nickel into bacterial cells, supplying the essential cofactor for virulence enzymes including urease, NiFe-hydrogenase, and Ni-glyoxalase. Because mammals produce no known nickel-requiring proteins, these transporters represent …