Mechanisms8 sources
Farnesoid X Receptor (FXR)
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Search: “FXR”
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Mechanisms8 sources
Bile Acid Metabolism
Bile acids are cholesterol-derived amphipathic molecules synthesized in the liver, secreted into the duodenum, and extensively modified by gut bacteria. The host-microbe co-metabolism of bile acids creates a signaling network with profound effects on lipid metabolism, g…
Mechanisms4 sources
Bile Salt Hydrolase (BSH)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms3 sources
Ursodeoxycholic Acid (UDCA)
Ursodeoxycholic acid is a hydrophilic secondary bile acid used therapeutically for primary biliary cholangitis (PBC), gallstone dissolution, and cholestatic liver disease. It is also a microbial metabolite — gut bacteria (7α/β-hydroxysteroid dehydrogenases) convert chen…