Revision history:
Gastric Cancer

Revised “Connections”: now reads “hydrogenase; dietary nickel fuels virulence - cadmium -- IARC Group 1 carcinogen”.

Revised “Connections”: changed “hydrogenase; dietary nickel fuels virulence - Hydrogenase -- nickel-dependent energy enzyme enabling full colonization density - cadmium -- IARC Group 1 carcinogen” to “hydrogenase; dietary nickel fuels virulence - cadmium -- IARC Group 1 carcinogen”.

Revised “Connections”: now reads “hydrogenase; dietary nickel fuels virulence - Hydrogenase -- nickel-dependent energy enzyme enabling full”.

Revised “Connections”: changed “hydrogenase; dietary nickel fuels virulence - hydrogenase -- nickel-dependent energy enzyme enabling full” to “hydrogenase; dietary nickel fuels virulence - Hydrogenase -- nickel-dependent energy enzyme enabling full”.

Revised “Step 1: Nickel Enables Colonization”: now reads “H. pylori cannot colonize. - [Ni-Fe] hydrogenase -- oxidizes molecular H2 (produced by”.

Revised “Step 1: Nickel Enables Colonization”: changed “H. pylori cannot colonize. - [Ni-Fe] Hydrogenase -- oxidizes molecular H2 (produced by” to “H. pylori cannot colonize. - [Ni-Fe] hydrogenase -- oxidizes molecular H2 (produced by”. Revised “Nickel (Beyond H. pylori)”: changed “cancer; gastric route less studied) - Dietary nickel exposure in H. pylori-infected individuals” to “cancer; gastric route less studied) - dietary nickel exposure in H. pylori-infected individuals”. Revised “Prevention and Therapeutic Angles”: changed “antioxidant defense via glutathione peroxidase - Probiotics -- Lactobacillus supplementation during H. pylori” to “antioxidant defense via glutathione peroxidase - probiotics -- Lactobacillus supplementation during H. pylori”.

Revised “Step 3: The Carcinogenic Cascade”: now reads “step is driven by chronic inflammation nf kappa b, oxidative stress, DNA damage, immune responses (Th1/Th17 -- see immune”.

Revised “Step 3: The Carcinogenic Cascade”: changed “step is driven by chronic inflammation (nf kappa b, oxidative stress, DNA damage), immune responses (Th1/Th17 -- see immune” to “step is driven by chronic inflammation nf kappa b, oxidative stress, DNA damage, immune responses (Th1/Th17 -- see immune”.

Added associated conditions: colorectal-cancer; pancreatic-cancer; gerd.

Added “Connections”: - helicobacter pylori -- the causative organism; nickel-dependent urease and hydrogenase power colonization and CagA delivery - nickel -- essential cofactor for H. pylori urease and [Ni-Fe]…

Added “Connections”: - helicobacter pylori -- the causative organism; nickel-dependent urease and hydrogenase power colonization and CagA delivery - nickel -- essential cofactor for H. pylori urease and [Ni-Fe]… Removed “See Also”: - helicobacter pylori -- the causative organism - hydrogenase -- the nickel-dependent energy enzyme enabling virulence - nickel -- the metal enabling H. pylori's cancer-promoting machinery - metal…

Created “Gastric Cancer”: The fifth most common cancer worldwide and third leading cause of cancer death, with over 1 million new cases annually. Gastric cancer stands unique in this wiki as the disease where a single…

Created “Gastric Cancer”: The fifth most common cancer worldwide and third leading cause of cancer death, with over 1 million new cases annually. Gastric cancer stands unique in this wiki as the disease where a single… Published sections: Gastric Cancer; Step 1: Nickel Enables Colonization; Step 2: Nickel Powers Virulence; Step 3: The Carcinogenic Cascade; Cadmium; Lead; Iron; Nickel (Beyond H. pylori); The Gastric Microbiome Beyond H. pylori; Dietary Risk Factors; Prevention and Therapeutic Angles; See Also.