Human AHR cellular context. The separated teaching forms do not establish protein conformation, ligand binding, translocation, DNA interaction, transcription, pathway activity, exposure response, biomarker status, or diagnosis.
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- Aryl Hydrocarbon Receptorbiological-process
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This page serves as a cross-reference point for the existing AhR (Aryl Hydrocarbon Receptor) concept page, which provides comprehensive coverage of AhR signaling, microbiome-derived ligands, and immune regulation.
The aryl hydrocarbon receptor is a ligand-activated transcription factor that integrates microbial, dietary, and environmental signals to regulate gut barrier integrity, immune tolerance, and Metal-Driven Inflammation.
Originally identified as a xenobiotic sensor (binding dioxins and polycyclic aromatic hydrocarbons), AhR is now recognized as a critical node in the microbiome-immune axis, where microbial tryptophan metabolites serve as its primary endogenous ligands.
For full coverage, see AhR (Aryl Hydrocarbon Receptor).
Contents
1. Key Cross-ReferencesKey Cross-References#
- AhR (Aryl Hydrocarbon Receptor)—comprehensive concept page
- Serotonin—3-IAld/AhR/TPH1 pathway tipping tryptophan toward serotonin
- Indoxyl Sulfate—toxic tryptophan metabolite; contrast to protective AhR ligands
- Lactobacillus—major producer of AhR ligands (3-IAld, ILA)
- Anaerostipes—ILA production linking to AhR immunity
- Necrotizing Enterocolitis—maternal AhR activation protects neonatal gut
- Celiac Disease—altered indole/AhR ligand production
- Bacteroides thetaiotaomicron—indole-derived AhR ligand production
References 8
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Natalia A. Borges, Amanda F. Barros, Lia S. Nakao et al. (2016). Protein-Bound Uremic Toxins from Gut Microbiota and Inflammatory Markers in CKD. Journal of Renal Nutrition.
- 2
Friederike Gutmann, Lina Samira Bahr, Ulrike Bruning et al. (2025). Functional Microbiome Reprogramming Links Dietary Interventions to Neuroinflammatory Outcomes in Multiple Sclerosis. Research Square (preprint).
- 3
Shokufeh Ghasemian Sorboni, Hanieh Shakeri Moghaddam, Reza Jafarzadeh-Esfehani et al. (2023). Ghasemian Sorboni 2023 — Comprehensive Review on Gut Microbiome in Neurological Disorders. Unknown.
- 4
Various (2023). Metabolic Pathways 2023-2025 — Gut Microbiome Metabolic Activity in Type 1 Diabetes. Various.
- 5
Allison M. Plummer, Yvette L. Matos, Henry C. Lin et al. (2023). Plummer et al 2023 — Gut-Brain Pathogenesis of Post-Acute COVID-19 Neurocognitive Symptoms. Frontiers in Neuroscience.
- 6
Nicholas Dopkins, William Becker, Kathryn Miranda et al. (2021). Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor. Frontiers in Pharmacology.
- 7
Benedetta Parodi, Nicole Kerlero de Rosbo (2021). The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease?. Frontiers in Immunology.
- 8
Qing Zhang, Liqian Lu, Jiao Wang et al. (2024). Metabolomic Profiling Reveals Step-Wise Alteration of Bile Acid Metabolism in Diabetic Kidney Disease. Nutrition and Diabetes.
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