Aryl Hydrocarbon Receptor (AhR)

This page serves as a cross-reference point for the existing ahr concept page, which provides comprehensive coverage of AhR signaling, microbiome-derived ligands, and immune regulation.

The aryl hydrocarbon receptor is a ligand-activated transcription factor that integrates microbial, dietary, and environmental signals to regulate gut barrier integrity, immune tolerance, and inflammation. Originally identified as a xenobiotic sensor (binding dioxins and polycyclic aromatic hydrocarbons), AhR is now recognized as a critical node in the microbiome-immune axis, where microbial tryptophan metabolites serve as its primary endogenous ligands.

For full coverage, see ahr.

Key Cross-References

References (8)

  1. Natalia A. Borges, Amanda F. Barros, Lia S. Nakao et al. (2016). Protein-Bound Uremic Toxins from Gut Microbiota and Inflammatory Markers in CKD. Journal of Renal Nutrition. doi:10.1053/j.jrn.2016.07.005
  2. Friederike Gutmann, Lina Samira Bahr, Ulrike Bruning et al. (2025). Functional Microbiome Reprogramming Links Dietary Interventions to Neuroinflammatory Outcomes in Multiple Sclerosis. Research Square (preprint). doi:10.21203/rs.3.rs-7434844/v1
  3. Shokufeh Ghasemian Sorboni, Hanieh Shakeri Moghaddam, Reza Jafarzadeh-Esfehani et al. (2023). Ghasemian Sorboni 2023 — Comprehensive Review on Gut Microbiome in Neurological Disorders. Unknown
  4. Various (2023). Metabolic Pathways 2023-2025 — Gut Microbiome Metabolic Activity in Type 1 Diabetes. Various
  5. Allison M. Plummer, Yvette L. Matos, Henry C. Lin et al. (2023). Plummer et al 2023 — Gut-Brain Pathogenesis of Post-Acute COVID-19 Neurocognitive Symptoms. Frontiers in Neuroscience. doi:10.3389/fnins.2023.1232480
  6. Nicholas Dopkins, William Becker, Kathryn Miranda et al. (2021). Tryptamine Attenuates Experimental Multiple Sclerosis Through Activation of Aryl Hydrocarbon Receptor. Frontiers in Pharmacology. doi:10.3389/fphar.2020.619265
  7. Benedetta Parodi, Nicole Kerlero de Rosbo (2021). The Gut-Brain Axis in Multiple Sclerosis. Is Its Dysfunction a Pathological Trigger or a Consequence of the Disease?. Frontiers in Immunology. doi:10.3389/fimmu.2021.718220
  8. Qing Zhang, Liqian Lu, Jiao Wang et al. (2024). Metabolomic Profiling Reveals Step-Wise Alteration of Bile Acid Metabolism in Diabetic Kidney Disease. Nutrition and Diabetes. doi:10.1038/s41387-024-00315-0

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