Type-species-anchored Sneathia reconstruction with seven slender straight-to-gently-curved rods. Representative, non-universal, non-diagnostic, and not a micrograph.
Scientific media record1 verified identifier
- Subject
- Sneathiataxon · genus
- Identifiers
- NCBITaxon:168808
- Review
- Editorial review completeIdentifiers authority-verified · Accessibility validated · · sneathia|sneathia-morphology-v1.webp
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- Trained-algorithmic mediaCreated with a trained generative algorithm and reviewed by WikiBiome for subject identity, scientific framing, identifiers, provenance, and accessibility.
- Scientific basis
- Sneathia — NCBI TaxonomySneathia — LPSNSneathia sanguinegens — LPSNSneathia clinical and morphology review
- License
- CC BY-SA 4.0Created
Sneathia is a genus of obligate anaerobic, Gram-negative bacteria in the phylum Fusobacteriota (formerly Fusobacteria). The primary species is S. sanguinegens (formerly Leptotrichia sanguinegens), with S. amnii also clinically significant.
Sneathia is a member of the BV-associated bacterial consortium alongside Gardnerella, Atopobium, Megasphaera, and Prevotella, and is emerging as a significant organism in preterm birth, HPV persistence, and reproductive tract microbiome studies.
Evidence map6 cited passagesInspect provenance +
Enriched in HPV-positive cervical microbiomes.
Elevated in vaginal samples associated with preterm birth risk.
Part of the statin-responsive BV microbiome—statins reduce Gardnerella vaginolysin and may affect the broader BV consortium.
Produces sialidase, contributing to mucosal barrier degradation alongside Atopobium.
Like other BV-associated organisms, Sneathia is depleted in cervical samples from endometriosis patients, part of the distinctive ecological shift away from the BV consortium toward Enterobacteriaceae dominance.
Emerging evidence of Sneathia in seminal fluid and male reproductive tract microbiome.
Contents
1. Vaginal Microbiome—BV Consortium2. Endometriosis—Cervical Depletion3. Male Reproductive Tract4. Cross-ReferencesVaginal Microbiome—BV Consortium#
Sneathia is enriched in BV and Community State Type IV vaginal microbiomes, co-occurring with the Gardnerella-Atopobium biofilm community. Enriched in HPV-positive cervical microbiomes.[1]Yang 2020 — Vaginal Microbiome Alterations in HPV16 Infection by Shotgun MetagenomicsQian Yang, Yaping Wang, Xinyi Wei et al. · 2020Open reference 1 ↓ Elevated in vaginal samples associated with preterm birth risk.[2]Pruski & Correia 2021 — Direct On-Swab Metabolic Profiling of Vaginal Microbiome Host Interactions During Pregnancy and Preterm BirthPamela Pruski, Gonçalo D. S. Correia, Holly V. Lewis et al. · 2021Open reference 2 ↓
Part of the statin-responsive BV microbiome—statins reduce Gardnerella vaginolysin and may affect the broader BV consortium.[3]Abdelmaksoud 2017 — Association between Statin Use, the Vaginal Microbiome, and Gardnerella vaginalis Vaginolysin-Mediated CytotoxicityAbdelmaksoud AA, Girerd PH, Garcia EM et al. · 2017Open reference 3 ↓
Produces sialidase, contributing to mucosal barrier degradation alongside Atopobium.[4]Roberts 2019 — Mucosal Lactoferrin Response to Genital Tract Infections Is Associated with Iron and Nutritional BiomarkersS. A. Roberts, L. Brabin, S. Diallo et al. · 2019Open reference 4 ↓
Endometriosis—Cervical Depletion#
Like other BV-associated organisms, Sneathia is depleted in cervical samples from endometriosis patients, part of the distinctive ecological shift away from the BV consortium toward Enterobacteriaceae dominance.[5]Ata 2019 — The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy ControlsBaris Ata, Sule Yildiz, Engin Turkgeldi et al. · 2019Open reference 5 ↓[6]Hicks et al. 2025 — Oral, Vaginal, and Stool Microbial Signatures in Patients With Endometriosis as Potential Diagnostic Non-Invasive BiomarkersChloe Hicks, Mathew Leonardi, Xin-Yi Chua et al. · 2025Open reference 6 ↓[7]Ser 2023 — Current Updates on the Role of Microbiome in Endometriosis: A Narrative ReviewHooi-Leng Ser, Siu-Jung Au Yong, Mohamad Nasir Shafiee et al. · 2023Open reference 7 ↓[8]Shen 2022 — Vaginal Microecological Characteristics of Women in Different Physiological and Pathological PeriodsLiping Shen, Wei Zhang, Yi Yuan et al. · 2022Open reference 8 ↓
Male Reproductive Tract#
Emerging evidence of Sneathia in seminal fluid and male reproductive tract microbiome.[9]Neto 2024 — Effect of Environmental Factors on Seminal Microbiome and Impact on Sperm QualityFilipe T. Lira Neto, Marina C. Viana, Federica Cariati et al. · 2024Open reference 9 ↓[10]Magill 2023 — Male Infertility and the Human MicrobiomeMagill RG, MacDonald SM · 2023Open reference 10 ↓
Cross-References#
- Gardnerella—primary BV biofilm initiator
- Atopobium—BV consortium partner; co-depleted in endometriosis
- Megasphaera—BV consortium partner
- Prevotella—BV consortium partner
- Endometriosis—cervical depletion pattern
- Bacterial Vaginosis—core BV-associated organism
References 11
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Qian Yang, Yaping Wang, Xinyi Wei et al. (2020). Yang 2020 — Vaginal Microbiome Alterations in HPV16 Infection by Shotgun Metagenomics. Frontiers in Cellular and Infection Microbiology.
- 2
Pamela Pruski, Gonçalo D. S. Correia, Holly V. Lewis et al. (2021). Pruski & Correia 2021 — Direct On-Swab Metabolic Profiling of Vaginal Microbiome Host Interactions During Pregnancy and Preterm Birth. Nature Communications.
- 3
Abdelmaksoud AA, Girerd PH, Garcia EM et al. (2017). Abdelmaksoud 2017 — Association between Statin Use, the Vaginal Microbiome, and Gardnerella vaginalis Vaginolysin-Mediated Cytotoxicity. PLOS ONE.
- 4
S. A. Roberts, L. Brabin, S. Diallo et al. (2019). Roberts 2019 — Mucosal Lactoferrin Response to Genital Tract Infections Is Associated with Iron and Nutritional Biomarkers. European Journal of Clinical Nutrition.
- 5
Baris Ata, Sule Yildiz, Engin Turkgeldi et al. (2019). Ata 2019 — The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls. Scientific Reports.
- 6
Chloe Hicks, Mathew Leonardi, Xin-Yi Chua et al. (2025). Hicks et al. 2025 — Oral, Vaginal, and Stool Microbial Signatures in Patients With Endometriosis as Potential Diagnostic Non-Invasive Biomarkers. BJOG: An International Journal of Obstetrics and Gynaecology.
- 7
Hooi-Leng Ser, Siu-Jung Au Yong, Mohamad Nasir Shafiee et al. (2023). Ser 2023 — Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review. Microorganisms.
- 8
Liping Shen, Wei Zhang, Yi Yuan et al. (2022). Shen 2022 — Vaginal Microecological Characteristics of Women in Different Physiological and Pathological Periods. Frontiers in Cellular and Infection Microbiology.
- 9
Filipe T. Lira Neto, Marina C. Viana, Federica Cariati et al. (2024). Neto 2024 — Effect of Environmental Factors on Seminal Microbiome and Impact on Sperm Quality. Frontiers in Endocrinology.
- 10
Magill RG, MacDonald SM (2023). Magill 2023 — Male Infertility and the Human Microbiome. Frontiers in Reproductive Health.
- 11
Jhommara Bautista, Carolina E. Echeverria, Ivan Maldonado-Noboa et al. (2025). Bautista 2025 — The Human Microbiome in Clinical Translation: From Bench to Bedside. Frontiers in Microbiology.
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