Selected type-species-anchored Fusicatenibacter spindle-shaped rods, shown as ten bodies in three single, two paired, and one three-cell grouping. This genus-level scientific reconstruction is representative, non-diagnostic, and not a micrograph.
Scientific media record1 verified identifier
- Subject
- Fusicatenibactertaxon · genus
- Identifiers
- NCBITaxon:1407607
- Review
- Editorial review completeIdentifiers authority-verified · Accessibility validated · · fusicatenibacter|fusicatenibacter-morphology-v1.webp
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- Trained-algorithmic mediaCreated with a trained generative algorithm and reviewed by WikiBiome for subject identity, scientific framing, identifiers, provenance, and accessibility.
- Scientific basis
- Fusicatenibacter — NCBI TaxonomyFusicatenibacter — LPSNFusicatenibacter saccharivorans gen. nov., sp. nov.Fusicatenibacter saccharivorans type strain — BacDive
- License
- CC BY-SA 4.0Created
Fusicatenibacter is a Gram-positive obligate anaerobic genus within the Lachnospiraceae (Firmicutes). The primary species, F. saccharivorans, was isolated from human feces and is recognized as a beneficial commensal that produces Butyrate and modulates intestinal immune responses.
Metal Dependencies#
Like other Lachnospiraceae, Fusicatenibacter requires iron for its fermentative enzymes but lacks aggressive iron acquisition systems. This makes it vulnerable to displacement by siderophore-producing Proteobacteria when luminal iron rises during Metal-Driven Inflammation—a pattern shared with Roseburia intestinalis and other butyrate producers.
Ecological Role#
F. saccharivorans produces extracellular polysaccharides that suppress pro-inflammatory cytokine production (TNF-alpha, IL-8) by intestinal epithelial cells. This positions it as an active immunomodulator, not merely a passive fermenter. Its butyrate output further supports colonocyte energy metabolism and barrier function.
Depletion of Fusicatenibacter may remove a brake on mucosal inflammation.
Conditions Associated#
Fusicatenibacter is consistently depleted in Inflammatory Bowel Disease (IBD) (both Crohn's disease and ulcerative colitis) and Colorectal Cancer. Its abundance correlates positively with remission in ulcerative colitis patients, making it a potential biomarker for mucosal healing and a candidate for next-generation probiotic development.
Cross-References#
- butyrate—metabolic output
- Lachnospiraceae—taxonomic family
- Iron—competitive vulnerability
- Inflammatory Bowel Disease (IBD)—depleted in disease
References 7
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Li Z, Tao X, Wang D et al. (2024). Alterations of the Gut Microbiota in Patients with Schizophrenia. Frontiers in Psychiatry.
- 2
Haijing Wang, Yuanjun Wang, Libin Yang et al. (2024). Wang 2024 — Integrated 16S rRNA sequencing and metagenomics insights into microbial dysbiosis and distinct virulence factors in inflammatory bowel disease. Frontiers in Microbiology.
- 3
Xiao-Ce Dai, Yi Yu, Si-Yu Zhou et al. (2024). Assessment of the Causal Relationship between Gut Microbiota and Cardiovascular Diseases: A Bidirectional Mendelian Randomization Analysis. BioData Mining.
- 4
Gong W, Jin G, Bao Y et al. (2025). Characteristics and potential diagnostic value of gut microbiota in ovarian tumor patients. Scientific Reports.
- 5
Zhu X, Zhang C, Feng S et al. (2024). Zhu et al. 2024 — Intestinal Microbiota Regulates the Gut-Thyroid Axis: The New Dawn of Improving Hashimoto Thyroiditis. Clinical and Experimental Medicine.
- 6
Youran Li, Pei Xiao, Rong Cao et al. (2024). Li 2024 — Oral Lyophilized FMT Effects and Microbiota Changes in ASD Children. Frontiers in Pediatrics.
- 7
Xiao-Ce Dai, Yi Yu, Si-Yu Zhou et al. (2024). Assessment of the causal relationship between gut microbiota and cardiovascular diseases: a bidirectional Mendelian randomization analysis. BioData Mining.
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