Bacteroidaceae

Bacteroidaceae is a family of obligate anaerobic, Gram-negative bacteria in the order bacteroidales. The dominant genus is bacteroides, which includes B. fragilis, B. vulgatus, B. thetaiotaomicron, and B. uniformis. Bacteroidaceae are among the most abundant gut bacteria, specializing in complex polysaccharide degradation and bile acid metabolism.

Key Roles

  • Polysaccharide degradation: Extensive PUL (polysaccharide utilization loci) systems for dietary fiber and host glycan breakdown.
  • Bile acid metabolism: Bile salt hydrolases deconjugate primary bile acids.
  • CRC: Altered Bacteroidaceae abundance in CRC-adenoma progression [1].
  • Virome interactions: Bacteroidaceae-targeting phages modulate family abundance in metabolic syndrome [2] [3].
  • Statin effects: Rosuvastatin alters Bacteroidaceae abundance [4].

Cross-References

References (4)

  1. Xiaopeng Li, Jiahui Feng, Zhanggui Wang et al. (2023). Features of combined gut bacteria and fungi from a Chinese cohort of colorectal cancer, colorectal adenoma, and post-operative patients. Frontiers in Microbiology. doi:10.3389/fmicb.2023.1236583
  2. Patrick A. de Jonge, Koen Wortelboer, Torsten P. M. Scheithauer et al. (2022). Gut Virome Profiling Identifies a Widespread Bacteriophage Family Associated with Metabolic Syndrome. Nature Communications. doi:10.1038/s41467-022-31390-5
  3. Kosuke Fujimoto, Daichi Miyaoka, Satoshi Uematsu (2022). Characterization of the human gut virome in metabolic and autoimmune diseases. Inflammation and Regeneration. doi:10.1186/s41232-022-00218-6
  4. Yinhui Liu, Xiaobo Song, Huimin Zhou et al. (2018). Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo. Frontiers in Microbiology. doi:10.3389/fmicb.2018.00530

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