Sphingobium

Overview

Sphingobium is a genus of Gram-negative, aerobic bacteria within the family Sphingomonadaceae. Primarily known as environmental organisms capable of degrading aromatic compounds, Sphingobium species have been unexpectedly identified in human microbiome studies of the reproductive tract and gut.

Disease Associations

In endometriosis, Sphingobium is enriched in peritoneal fluid, representing one of the non-classical microbiome niches where bacterial communities contribute to local inflammatory environments ([1]). Its presence in this typically sterile compartment raises questions about bacterial translocation and the breakdown of mucosal barriers in endometriotic disease.

Sphingobium has also been detected in metagenomic profiling of gut microbiota associated with colorectal adenoma ([2]) and in studies of the gut microbiota's influence on male reproductive function ([3]).

Cross-References

References (3)

  1. Wei W, Zhang X, Tang H et al. (2020). Microbiota composition and distribution along the female reproductive tract of women with endometriosis. Annals of Clinical Microbiology and Antimicrobials. doi:10.1186/s12941-020-00356-0
  2. Saito K, Koido S, Odamaki T et al. (2019). Metagenomic Analyses of the Gut Microbiota Associated with Colorectal Adenoma. PLOS ONE. doi:10.1371/journal.pone.0212406
  3. Hui Cai, Xuanhong Cao, Dezhe Qin et al. (2022). Cai 2022 — Gut Microbiota Supports Male Reproduction via Nutrition, Immunity, and Signaling. Frontiers in Microbiology. doi:10.3389/fmicb.2022.977574

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