WikiBiomeThe human microbiome encyclopediaThis record shows only material changes published on this page, including changes to its content, evidence, conclusions, or author context. Internal processes and discussion activity are excluded. Pending, declined, and withdrawn proposals remain private. Each entry links to its source revision.
Revised “Functional Significance”: changed “butyrate — colonocyte fuel, HDAC inhibitor, barrier protector, Treg inducer. 2. Fiber degradation” to “butyrate — colonocyte fuel, HDAC inhibitor, tight junction and epithelial-barrier protector, Treg inducer. 2. Fiber degradation”.
wiki/entities/ruminococcaceae.mdAdded “Ruminococcaceae”: Ruminococcaceae is a family of obligate anaerobic, Gram-positive bacteria in the order Clostridiales (phylum Firmicutes) that represents one of the most important butyrate-producing and… Added “Why Ruminococcaceae Depletion Matters”: Ruminococcaceae depletion is among the most consistent microbiome findings across disease states — paralleling and overlapping with lachnospiraceae depletion: - Schizophrenia: Ruminococcaceae… Added “Functional Significance”: Ruminococcaceae's depletion removes: 1. butyrate — colonocyte fuel, HDAC inhibitor, barrier protector, Treg inducer. 2. Fiber degradation — cellulose, xylan, and resistant starch breakdown… Added “Metal Connection”: Butyrate production by Ruminococcaceae depends on iron-sulfur cluster enzymes (butyryl-CoA dehydrogenase). Heavy metal disruption of iron homeostasis impairs the family's core metabolic function. Added “Cross-References”: - faecalibacterium prausnitzii — dominant butyrate-producing species - lachnospiraceae — co-depleted butyrate-producing family - butyrate — primary metabolic output - short chain fatty acids — broader… Added citations to “Why Ruminococcaceae Depletion Matters”: li 2024 alterations gut microbiota schizophrenia vote counting; theleritis 2024 gut dysbiosis first episode psychosis review; bronzini 2023 feeding gut microbiome ms; ross 2024 diet gut microbiome interplay health disease; latorre perez 2021 spanish gut microbiome mediterranean diet. Added references: li-2024-alterations-gut-microbiota-schizophrenia-vote-counting; theleritis-2024-gut-dysbiosis-first-episode-psychosis-review; bronzini-2023-feeding-gut-microbiome-ms; ross-2024-diet-gut-microbiome-interplay-health-disease; latorre-perez-2021-spanish-gut-microbiome-mediterranean-diet. Added key enzymes: butyryl-CoA-dehydrogenase; cellulosome; xylanase. Added metal dependencies: iron.
wiki/entities/ruminococcaceae.mdRevised “Butyrate Production”: changed “of epithelial energy). - Butyrate maintains gut barrier integrity by promoting tight junction protein expression.” to “of epithelial energy). - Butyrate maintains gut-barrier-integrity by promoting tight junction protein expression.”.
wiki/concepts/ruminococcaceae.mdCreated “Ruminococcaceae”:
wiki/entities/ruminococcaceae.mdCreated “Ruminococcaceae”: Ruminococcaceae is a family within the phylum Firmicutes (class Clostridia, order Eubacteriales) that includes many of the gut's most important fiber-degrading and butyrate-producing bacteria. The… Published sections: Ruminococcaceae; Fiber Degradation -- The Primary Fermenters; Butyrate Production; Oxygen and pH Sensitivity; Metal Vulnerability; Disease Associations -- Consistent Depletion; Ruminococcus gnavus -- The Pathobiont; The Opposing Signature; Open Questions; Cross-References.
wiki/concepts/ruminococcaceae.md