Rikenella

Rikenella is a genus of obligate anaerobic, Gram-negative bacteria in the family Rikenellaceae (phylum Bacteroidetes). The primary species is R. microfusus. In the WikiBiome vault, Rikenella is consistently depleted across disease states — a protective commensal whose loss is part of the dysbiotic signature.

Disease Associations

  • CVD: Bidirectional MR suggests causal protective association [1].
  • Schizophrenia: Depleted in schizophrenia gut microbiome [2].
  • T1D: Early-life antibiotic exposure depletes Rikenella, associated with autoimmune diabetes [3].
  • Endometriosis: Depleted in endometriosis gut microbiota [4].
  • Prostate: Part of altered gut microbiome in prostatic disease [5].
  • QTL-linked: Abundance is genetically influenced (QTL-mapped) and responsive to diet and sex [6].

Cross-References

References (6)

  1. Xiao-Ce Dai, Yi Yu, Si-Yu Zhou et al. (2024). Assessment of the Causal Relationship between Gut Microbiota and Cardiovascular Diseases: A Bidirectional Mendelian Randomization Analysis. BioData Mining. doi:10.1186/s13040-024-00356-2
  2. Szeligowski T, Yun AL, Lennox BR et al. (2020). The Gut Microbiome and Schizophrenia: The Current State of the Field and Clinical Applications. Frontiers in Psychiatry. doi:10.3389/fpsyt.2020.00156
  3. Sophie Candon, Alicia Perez-Arroyo, Cindy Marquet et al. (2015). Candon 2015 — Antibiotics in Early Life Alter the Gut Microbiome and Increase Disease Incidence in a Spontaneous Mouse Model of Autoimmune Diabetes. PLoS ONE. doi:10.1371/journal.pone.0125448
  4. Svensson A, Brunkwall L, Roth B et al. (2021). Associations Between Endometriosis and Gut Microbiota. Reproductive Sciences. doi:10.1007/s43032-021-00506-5
  5. Hongliang Cao, Difei Zhang, Pengyu Wang et al. (2024). Cao 2024 — Gut Microbiome: A Novel Preventive and Therapeutic Target for Prostatic Disease. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2024.1431088
  6. Anna C. Salvador, M. Nazmul Huda, Danny Arends et al. (2023). Salvador 2023 — Strain, Sex, and Diet-Dependent Modulation of Gut Microbiota Reveals Candidate Keystone Organisms. Microbiome. doi:10.1186/s40168-023-01588-w

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