Rikenella is a genus of obligate anaerobic, Gram-negative bacteria in the family Rikenellaceae (phylum Bacteroidetes). The primary species is R. microfusus. In the WikiBiome vault, Rikenella is consistently depleted across disease states — a protective commensal whose loss is part of the dysbiotic signature.
Disease Associations
- CVD: Bidirectional MR suggests causal protective association dai 2024 bidirectional mr gut microbiota cvd.
- Schizophrenia: Depleted in schizophrenia gut microbiome szeligowski 2020 gut microbiome schizophrenia review.
- T1D: Early-life antibiotic exposure depletes Rikenella, associated with autoimmune diabetes candon 2015 antibiotics early life gut microbiome autoimmune diabetes nod.
- Endometriosis: Depleted in endometriosis gut microbiota svensson 2021 endometriosis gut microbiota associations.
- Prostate: Part of altered gut microbiome in prostatic disease cao 2024 gut microbiome preventive therapeutic prostatic disease.
- QTL-linked: Abundance is genetically influenced (QTL-mapped) and responsive to diet and sex salvador 2023 strain sex diet gut microbiota qtl keystone.
Cross-References
- bacteroidetes — phylum context
- dysbiosis — Rikenella depletion as disease marker