Added “Megasphaera”: Megasphaera is a genus of obligate anaerobic, Gram-negative bacteria in the family Veillonellaceae (class Negativicutes, phylum Firmicutes). The genus occupies two distinct ecological niches — the…
Added “Megasphaera”: Megasphaera is a genus of obligate anaerobic, Gram-negative bacteria in the family Veillonellaceae (class Negativicutes, phylum Firmicutes). The genus occupies two distinct ecological niches — the… Added “Vaginal Microbiome — BV Association”: Megasphaera is one of the BV-associated bacteria (BVAB) consistently enriched when Lactobacillus-dominant vaginal communities shift toward dysbiosis: - Part of the… Added “Endometriosis — Cervical Depletion”: Counterintuitively, Megasphaera is depleted (not enriched) in cervical samples from endometriosis patients, alongside Gardnerella, Atopobium, and Prevotella, while Escherichia/Shigella and Dialister… Added “Gut Microbiome — SCFA Producer”: In the gut, Megasphaera plays a different role as a butyrate and propionate producer: - M. elsdenii is one of the most efficient lactate-utilizing organisms in the gut, converting lactate to butyrate… Added “The Context-Dependence Problem”: Megasphaera illustrates why genus-level classification as "beneficial" or "pathogenic" fails: | Niche | Role | Implication | |-------|------|-------------| | Vagina (Lactobacillus-depleted) |… Added “Cross-References”: - gardnerella — co-enriched in BV; co-depleted in endometriosis cervical samples - atopobium — BV consortium partner - sneathia — BV consortium partner - prevotella — BV consortium partner; also… Added citations to “Vaginal Microbiome — BV Association”: yang 2020 vaginal microbiome hpv16 shotgun metagenomics; pruski 2021 desi ms vaginal microbiome preterm birth. Added citations to “Endometriosis — Cervical Depletion”: ata 2019 endobiota study vaginal cervical gut microbiota endometriosis; hicks 2025 oral vaginal stool microbial signatures endometriosis; ser 2023 current updates microbiome endometriosis review; shen 2022 vaginal microecological characteristics endometriosis; miyashira 2022 microbiome and endometriosis. Added citations to “Gut Microbiome — SCFA Producer”: liu 2019 altered gut microbiota scfa chinese children asd; takeda 2022 gut microbiota premenstrual symptoms; su 2020 gut microbiota immune imbalance graves; zhou 2020 fecal microbiota ppd. Added references: ata-2019-endobiota-study-vaginal-cervical-gut-microbiota-endometriosis; hicks-2025-oral-vaginal-stool-microbial-signatures-endometriosis; ser-2023-current-updates-microbiome-endometriosis-review; shen-2022-vaginal-microecological-characteristics-endometriosis; miyashira-2022-microbiome-and-endometriosis; yang-2020-vaginal-microbiome-hpv16-shotgun-metagenomics; pruski-2021-desi-ms-vaginal-microbiome-preterm-birth; chen-2021-chlamydia-vaginal-microbiota-tubal-infertility; liu-2019-altered-gut-microbiota-scfa-chinese-children-asd; takeda-2022-gut-microbiota-premenstrual-symptoms; su-2020-gut-microbiota-immune-imbalance-graves; ho-2024-colorectal-cancer-virome-alterations-persistence-surgery; zhou-2020-fecal-microbiota-ppd. Added key enzymes: butyrate-kinase; butyryl-CoA-transferase. Added metal dependencies: iron.
wiki/entities/megasphaera.md