Finegoldia

Overview

Finegoldia is a genus of Gram-positive, strictly anaerobic cocci, with Finegoldia magna as the primary species of clinical relevance. Formerly classified within Peptostreptococcus, this organism inhabits mucosal surfaces including the vaginal, skin, and gastrointestinal microbiomes.

Reproductive Tract Associations

Finegoldia is a recognized component of both the vaginal and seminal microbiomes. In endometriosis, it appears as part of the altered vaginal microbial community, potentially contributing to local inflammatory cascades ([1]). It has also been identified in male reproductive tract microbiome profiling, where its presence correlates with compositional shifts associated with subfertility ([2]).

Gut-Brain Axis Associations

Maternal gut Finegoldia abundance has been associated with postpartum depression (PPD) and infant neurodevelopmental outcomes, positioning this genus within the gut-brain axis during the perinatal period ([3]).

Cross-References

References (3)

  1. Hooi-Leng Ser, Siu-Jung Au Yong, Mohamad Nasir Shafiee et al. (2023). Ser 2023 — Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review. Microorganisms. doi:10.3390/microorganisms11020360
  2. Nerea Molina Morales (2023). Molina Morales 2023 — The Microbiome of the Male Reproductive Tract: Uncovering Its Composition and Origins. Doctoral Thesis, Universidad de Granada. doi: https://hdl.handle.net/10481/85100 (malformed — flagged for audit)
  3. Lepeng Zhou, Linghong Tang, Chuhui Zhou et al. (2024). Zhou 2024 — Association of Maternal Postpartum Depression Symptoms with Infant Neurodevelopment and Gut Microbiota. Frontiers in Psychiatry. doi:10.3389/fpsyt.2024.1385229

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