WikiBiomeThe human microbiome encyclopediaThis record shows only material changes published on this page, including changes to its content, evidence, conclusions, or author context. Internal processes and discussion activity are excluded. Pending, declined, and withdrawn proposals remain private. Each entry links to its source revision.
Revised “Nickel”: changed “C. freundii harbors NiFe-hydrogenase for anaerobic hydrogen oxidation, linking it” to “C. freundii harbors NiFe hydrogenase for anaerobic hydrogen oxidation, linking it”.
wiki/entities/citrobacter.mdAdded “Citrobacter”: Citrobacter is a genus of Gram-negative, facultatively anaerobic bacteria in the Enterobacteriaceae family, named for its ability to utilize citrate as a sole carbon source. Species include C.… Added “Iron”: Like other Enterobacteriaceae, Citrobacter produces enterobactin and other siderophores for iron acquisition. Iron availability in the inflamed gut favors Citrobacter expansion alongside E. coli and… Added “Nickel”: C. freundii harbors NiFe-hydrogenase for anaerobic hydrogen oxidation, linking it to the nickel-dependent pathogen network in this wiki. Added “Arsenic Biotransformation”: Citrobacter species possess arsenic reductase and methyltransferase enzymes that convert inorganic arsenic to organic forms. This biotransformation capacity means Citrobacter abundance directly… Added “Necrotizing Enterocolitis (NEC)”: Citrobacter is enriched in the preterm infant gut prior to NEC onset, as part of the Enterobacteriaceae bloom that precedes intestinal necrosis. Iron and nickel availability in preterm formula may… Added “Colorectal Cancer”: Enriched in CRC microbiome alongside other Enterobacteriaceae. C. rodentium is the standard mouse model for studying colonic epithelial attachment and effacement — the mechanism by which EHEC causes… Added “Chronic Kidney Disease”: Citrobacter enrichment correlates with CKD severity and uremic toxin accumulation. Added “Other”: - Part of the dysbiotic gut microbiota in endometriosis mouse models. - Enriched in pancreatic cancer-associated microbiome. - Metallomics relevance in critical care infections. Added “Cross-References”: - enterobacteriaceae — family-level bloom in dysbiosis - iron — siderophore-dependent; iron availability drives expansion - nickel — NiFe-hydrogenase for anaerobic hydrogen oxidation - arsenic —… Added citations to “Iron”: khorsand 2022 enterobacteriaceae ecoli ibd ibdmdb metagenomics. Added citations to “Nickel”: pendergrass 2026 nickel nec preterm gut. Added citations to “Arsenic Biotransformation”: mcdermott 2020 arsenic gastrointestinal tract microbiome. Added citations to “Necrotizing Enterocolitis (NEC)”: pendergrass 2026 nickel nec preterm gut; lin 2025 nec serum metabolomics fecal microbiome. Added citations to “Colorectal Cancer”: marchesi 2011 towards human crc microbiome; liu 2023 colorectal cancer progression microbiome signature. Added citations to “Chronic Kidney Disease”: wang 2023 perturbed microbiome metabolomes ckd severity; margiotta 2020 gut microbiota frailty elderly ckd. Added citations to “Other”: ni 2020 fecal metabolomics gut microbiota endometriosis mice; pourali 2024 microbiome biomarker therapeutic target pancreatic cancer; patil 2021 infection metallomics critical care. Added references: khorsand-2022-enterobacteriaceae-ecoli-ibd-ibdmdb-metagenomics; pendergrass-2026-nickel-nec-preterm-gut; lin-2025-nec-serum-metabolomics-fecal-microbiome; marchesi-2011-towards-human-crc-microbiome; liu-2023-colorectal-cancer-progression-microbiome-signature; wang-2023-perturbed-microbiome-metabolomes-ckd-severity; margiotta-2020-gut-microbiota-frailty-elderly-ckd; mcdermott-2020-arsenic-gastrointestinal-tract-microbiome; patil-2021-infection-metallomics-critical-care; khan-2011-novel-approach-enterobacteriaceae-identification-clinical; ni-2020-fecal-metabolomics-gut-microbiota-endometriosis-mice; pourali-2024-microbiome-biomarker-therapeutic-target-pancreatic-cancer. Added key enzymes: enterobactin; citrate-lyase; NiFe-hydrogenase. Added metal dependencies: iron; nickel.
wiki/entities/citrobacter.mdCreated “Citrobacter”:
wiki/entities/citrobacter.md