Bifidobacterium Bifidum

Bifidobacterium bifidum is an obligate anaerobic, Gram-positive species that specializes in human milk oligosaccharide (HMO) and mucin glycan degradation. It is one of the earliest colonizers of the infant gut and a widely used probiotic species.

Key Associations

  • Lead sensitivity: Prenatal lead exposure depletes B. bifidum in childhood gut microbiome, suggesting metal vulnerability [1].
  • Schizophrenia RCT: Component of probiotic formulation (with L. acidophilus) + vitamin D improving metabolic parameters in schizophrenia [2].
  • Male fertility: Oxidative stress modulation via gut microbiota [3].
  • CRC-adenoma: Altered in CRC progression [4].

Cross-References

References (4)

  1. Shoshannah Eggers, Vishal Midya, Moira Bixby et al. (2023). Eggers 2023 — Prenatal lead exposure is negatively associated with gut microbiome in childhood (PROGRESS cohort). Frontiers in Microbiology. doi:10.3389/fmicb.2023.1193919
  2. Ghaderi A, Banafshe HR, Mirhosseini N et al. (2019). Clinical and Metabolic Response to Vitamin D Plus Probiotic in Schizophrenia Patients. BMC Psychiatry. doi:10.1186/s12888-019-2059-x
  3. Natalia Kurhaluk, Piotr Kaminski, Halina Tkaczenko (2025). Kurhaluk 2025 — Oxidative Stress, Antioxidants, Gut Microbiota and Male Fertility. Cellular Physiology and Biochemistry. doi:10.33594/000000802
  4. Xiaopeng Li, Jiahui Feng, Zhanggui Wang et al. (2023). Features of combined gut bacteria and fungi from a Chinese cohort of colorectal cancer, colorectal adenoma, and post-operative patients. Frontiers in Microbiology. doi:10.3389/fmicb.2023.1236583

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