Gemella

Gemella is a genus of Gram-positive, facultatively anaerobic cocci that are normal commensals of the oral cavity. Species include G. morbillorum, G. haemolysans, and G. sanguinis. In the WikiBiome context, Gemella is notable for its oral-gut translocation pattern — an oral commensal that appears in gut and tumor microbiome studies, suggesting translocation as a marker of barrier disruption.

Oral-Gut Translocation

Other Associations

  • ASD: Depleted in gut microbiota of young ASD children [4].
  • Endometriosis: Part of vaginal/cervical microbiome shifts [5] [6].
  • Genital tract: Abundance modulated by mucosal lactoferrin levels [7].

Cross-References

References (7)

  1. Suga D, Mizutani H, Fukui S et al. (2022). The Gut Microbiota Composition in Patients with Right- and Left-Sided Colorectal Cancer and After Curative Colectomy, as Analyzed by 16S rRNA Gene Amplicon Sequencing. BMC Gastroenterology. doi:10.1186/s12876-022-02382-y
  2. Hou X, Zheng Z, Wei J et al. (2022). Effects of Gut Microbiota on Immune Responses and Immunotherapy in Colorectal Cancer. Frontiers in Immunology. doi:10.3389/fimmu.2022.1030745
  3. Liang T, Liu F, Liu L et al. (2021). Effects of Helicobacter pylori Infection on the Oral Microbiota of Reflux Esophagitis Patients. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2021.732613
  4. Lorena Coretti, Lorella Paparo, Maria Pia Riccio et al. (2018). Coretti 2018 — Gut Microbiota Features in Young Children With Autism Spectrum Disorders. Frontiers in Microbiology. doi:10.3389/fmicb.2018.03146
  5. Liping Shen, Wei Zhang, Yi Yuan et al. (2022). Shen 2022 — Vaginal Microecological Characteristics of Women in Different Physiological and Pathological Periods. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2022.959793
  6. Baris Ata, Sule Yildiz, Engin Turkgeldi et al. (2019). Ata 2019 — The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls. Scientific Reports. doi:10.1038/s41598-019-39700-6
  7. S. A. Roberts, L. Brabin, S. Diallo et al. (2019). Roberts 2019 — Mucosal Lactoferrin Response to Genital Tract Infections Is Associated with Iron and Nutritional Biomarkers. European Journal of Clinical Nutrition. doi:10.1038/s41430-019-0444-7

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