Flavobacterium

Overview

Flavobacterium is a genus of Gram-negative, aerobic bacteria within the phylum Bacteroidetes. Primarily environmental organisms found in soil and freshwater, Flavobacterium species have been identified in human microbiome studies of the cervical and reproductive tract, where their presence is considered atypical and potentially indicative of microbial community disruption.

Endometriosis Associations

In endometriosis, Flavobacterium has been detected in cervical mucus microbial communities, representing a departure from the Lactobacillus-dominated healthy cervical microbiome ([1]). Its presence may reflect compromised mucosal barriers or altered cervical immune defenses that permit environmental organisms to colonize the reproductive tract ([2]).

Cross-References

References (4)

  1. Akiyama K, Nishioka K, Khan KN et al. (2019). Molecular detection of microbial colonization in cervical mucus of women with and without endometriosis. American Journal of Reproductive Immunology. doi:10.1111/aji.13147
  2. Hooi-Leng Ser, Siu-Jung Au Yong, Mohamad Nasir Shafiee et al. (2023). Ser 2023 — Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review. Microorganisms. doi:10.3390/microorganisms11020360
  3. Kanoko Akiyama, Keisuke Nishioka, Khaleque N. Khan et al. (2019). Akiyama 2019 — Molecular Detection of Microbial Colonization in Cervical Mucus of Women With and Without Endometriosis. American Journal of Reproductive Immunology. doi:10.1111/aji.13147
  4. Magill RG, MacDonald SM (2023). Magill 2023 — Male Infertility and the Human Microbiome. Frontiers in Reproductive Health. doi:10.3389/frph.2023.1166201