Revision history:
COX-2 (Cyclooxygenase-2)

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Canonical recordcox-2Mechanisms

Tracked source files1wiki/concepts/cox-2.md

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Sep 7, 2026Karen Pendergrass

Revised “The Metal → NF-kB → COX-2 → PGE₂ Cascade”: now reads “metal exposure to prostaglandin-mediated disease: 1. heavy metals (cadmium, nickel, lead, arsenic) generate”.

Revised “The Metal → NF-kB → COX-2 → PGE₂ Cascade”: changed “metal exposure to prostaglandin-mediated disease: 1. Heavy metals (cadmium, nickel, lead, arsenic) generate” to “metal exposure to prostaglandin-mediated disease: 1. heavy metals (cadmium, nickel, lead, arsenic) generate”.

wiki/concepts/cox-2.md

May 4, 2026WikiBiome Deploy Bot

Created “COX-2 (Cyclooxygenase-2)”: Cyclooxygenase-2 (COX-2) is the inducible enzyme that converts arachidonic acid to prostaglandin H₂ — the precursor of prostaglandin E₂ (PGE₂), prostacyclin, and thromboxane. Unlike COX-1…

Created “COX-2 (Cyclooxygenase-2)”: Cyclooxygenase-2 (COX-2) is the inducible enzyme that converts arachidonic acid to prostaglandin H₂ — the precursor of prostaglandin E₂ (PGE₂), prostacyclin, and thromboxane. Unlike COX-1… Published sections: Overview; The Metal → NF-kB → COX-2 → PGE₂ Cascade; Microbiome Connection; NSAIDs: The COX-2 Paradox; Cancer Connection; Cross-References.

wiki/concepts/cox-2.md