Bifidobacterium Infantis

Bifidobacterium longum subsp. infantis (commonly called B. infantis) is the premier human milk oligosaccharide (HMO)-utilizing bacterium and the dominant species in the breastfed infant gut. It drives immune maturation, Treg induction, and pathogen exclusion in early life.

Clinical Evidence

  • Thyroidectomy: RCT showing probiotic (including B. infantis) reduces oral-gut dysbiosis post-thyroidectomy [1].
  • Hypothyroidism: Component of probiotic formulation tested alongside levothyroxine [2].
  • T2D/testosterone: Part of multi-strain probiotic in case report [3].
  • GDM: Depleted in gestational diabetes [4].
  • Ovarian cancer: Microbiome context [5].

Cross-References

References (5)

  1. Baiqiang Lin, Fuya Zhao, Yang Liu et al. (2022). Lin 2022 — Probiotics alleviate oral-gut microbiota dysbiosis in thyroid cancer patients after thyroidectomy: RCT. Frontiers in Endocrinology. doi:10.3389/fendo.2022.834674
  2. Giorgia Spaggiari, Giulia Brigante, Sara De Vincentis et al. (2017). Spaggiari 2017 — Probiotics (VSL#3) do not directly affect thyroid hormonal parameters in levothyroxine-treated hypothyroid patients. Frontiers in Endocrinology. doi:10.3389/fendo.2017.00316
  3. Anna Griffith, Adam Perlman, Tara Karr et al. (2026). Griffith 2026 — Lifestyle Changes and Probiotic Supplementation for Improving Longstanding Type 2 Diabetes in a Male Undergoing Testosterone Replacement Therapy. Frontiers in Endocrinology. doi:10.3389/fendo.2025.1754430
  4. J. Wei, Y. Qing, H. Zhou et al. (2022). Wei 2022 — 16S rRNA Gene Amplicon Sequencing of Gut Microbiota in Gestational Diabetes Mellitus. Journal of Endocrinological Investigation. doi:10.1007/s40618-021-01595-4
  5. Asangba AE, Chen J, Goergen KM et al. (2023). Asangba 2023 — Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response. Scientific Reports. doi:10.1038/s41598-023-27555-x

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