Summary
- Entity/concept pages scanned: ~389 (all with ≥2 sources)
- Paragraphs with contradiction language: 30
- Genuine supersessions applied: 2
- Biological complexity (not supersession cases): 28
- Both source summary pages updated: Yes (4 source pages annotated)
Supersessions Applied
1. Copper in Rheumatoid Arthritis — wiki/entities/copper.md
Conflict: Cu direction in RA serum
- Earlier work: yang 2016 copper farm soils rheumatoid arthritis (2016, cross-sectional, n=122, Taiwan) — Cu elevated in RA, correlated with ESR
- Superseding: arshad 2023 heavy metals rheumatoid arthritis (2023, case-control, n≈99, Pakistan) — Cu significantly lower in RA (P=0.04)
Evidence hierarchy: case-control > cross-sectional → arshad-2023 takes primary position.
Action: Rewrote RA section to lead with arshad-2023 finding; annotated yang-2016 as earlier cross-sectional work with geographic exposure differences. Updated both source summary pages with explicit conflict notes.
2. Copper in Autism Spectrum Disorder — wiki/entities/autism-spectrum-disorder.md
Conflict: Cu level in ASD
- Earlier work: zhou-2025-metals-asd-severity-hair-correlation (cross-sectional, n=181, hair biomarker) — Cu elevated, severity-correlated
- Superseding: lin-2024-trace-elements-asd-meta-analysis (systematic-review-meta-analysis, 4 studies, N=577, blood/serum) — No significant Cu difference (P=0.726)
Evidence hierarchy: systematic-review-meta-analysis > cross-sectional → lin-2024 null finding takes primary position.
Action: Rewrote Cu subsection to lead with meta-analytic null; annotated zhou-2025 as single-region study with different biomarker matrix. Updated both source summary pages.
Verified as Non-Supersession Cases
The remaining 28 contradiction-flagged paragraphs were reviewed and determined to be:
- Biological complexity (different strains, tissues, or conditions showing different patterns) — 18 cases
- Biomarker matrix differences (hair vs blood vs tissue — genuinely different measurements) — 5 cases
- Already properly annotated (existing supersession annotations in place) — 3 cases
- Uncertainty properly represented (page correctly notes inconclusive evidence) — 2 cases
No further action required.