STOP: Broad Spectrum Antibiotics For Crohn'S Disease
Overview
> Warning: Clinical Disclaimer: This STOP page represents a hypothesis based on mechanistic evidence and should NOT replace clinical judgment. Always consult with a qualified healthcare provider before modifying any treatment plan. Evidence quality ratings reflect the strength of the mechanistic reasoning, not RCT-level clinical proof.
References (2)
Coryell M, McAlpine M, Pinkham NV et al. (2018). The gut microbiome is required for full protection against acute arsenic toxicity in mouse models. Nature Communications. doi:10.1038/s41467-018-07803-9
★Yang JC, Zhao M, Chernikova D et al. (2024). ZIP8 A391T Crohn's Disease-Linked Risk Variant Induces Colonic Metal Ion Dyshomeostasis, Microbiome Compositional Shifts, and Inflammation. Digestive Diseases and Sciences. doi:10.3389/fimmu.2023.1183914