Ingest Resume — 2026 04 21

Last completed commit

`3867e177` — update: pmdd entity and signature — source density threshold crossed

Session summary

Ingested 7 source pages from the PMDD PDF folder (all new):

New source pages created (7):

  1. `nexha-2024-biological-rhythms-pmdd-systematic-review.md` — SR 25 studies, melatonin amplitude reduction + elevated nocturnal core body temp in PMDD (BMC Women's Health)
  2. `nabeh-2024-diabetes-pms-gut-microbiome-review.md` — DM↔PMS shared pathophysiology via gut dysbiosis/SCFAs; metformin/GLP-1 most favorable (Diabetes Therapy)
  3. `quaranta-2019-fmt-female-reproductive-tract-diseases.md` — FMT for PCOS/endometriosis/BV; letrozole rat PCOS model normalized by FMT; gut-vagina LPS/NF-kB axis (Frontiers Immunology) — filed under condition: pcos
  4. `yang-2023-childhood-asthma-allergy-premenstrual-disorders.md` — Prospective cohort n=6,524; childhood asthma aRR 1.20, food allergy aRR 1.28 for PMDs in adulthood (Nature Mental Health)
  5. `fakruddin-2025-probiotics-menstrual-health-systematic-review.md` — SR 15 studies; L. casei PMS RCT (n=100, 3 months), estrobolome modulation mechanism (Microbial Bioactives)
  6. `rocha-filho-2011-essential-fatty-acids-pms-rct.md` — RCT n=116; 2g/day EFA (GLA/PUFA) > placebo for PMS symptoms at 6 months; no prolactin/cholesterol effect (Reproductive Health)
  7. `itriyeva-2022-pms-pmdd-adolescents-review.md` — ALLO-GABA-A receptor mechanism; SSRIs (intermittent); drospirenone OCP; calcium 1200mg best supplement evidence (Curr Probl Pediatr Adolesc Health Care)

Entity/signature updates:

  • `wiki/entities/pmdd.md` — stub demoted (now 6 sources, threshold 5); circadian rhythm and DM comorbidity sections added
  • `wiki/signatures/pmdd-signature.md` — sources updated to 6; circadian features added to ecological_features
  • `wiki/entities/pcos.md` — quaranta-2019 added (source_count: 22)
  • `wiki/entities/endometriosis.md` — quaranta-2019 added (source_count: 11)

PMDD PDF triage completed:

All ~65 PDFs in `raw/Premenstrual Dysphoric Disorder (PMDD)/` reviewed. Triage outcome:

  • Ingested this session (7): listed above
  • Already ingested in prior sessions (25+): takeda-2022, yao-2024, cheng-2025, pan-2025, bengi-2025, gao-2023, lin-2023, liu-2014, shi-2024, yang-2025, yu-2025, slyepchenko-2021, takeda-2023, syan-2018, draper-2018, guo-2025, nguyen-2017, sundstrom-poromaa-2023, liang-2023, etyemez-2025, li-2020
  • Misfiled — not PMDD relevant (~30): UC papers, PCOS papers, preterm birth, MS, CRC, honeybee, fine motor skills, schizophrenia MetS, T3SS, heavy metals/ADHD, adolescent RTIs, Metoprolol metabolomics, PCOS exercise/virome/drospirenone, psychology of anger, HormoneFix bonus PDF
  • Skip — low quality/thesis: Rauniyar (PPD thesis), Rosso thesis, Kelvin 2021 (n=85 negative), Wei 2022 editorial, Ni 2025 qualitative psychedelics, 19146011 (Brac thesis), 32051 (Thessaly MSc), Exploring Female Repro Health (Scholar's Digest no DOI), conference abstract book (140161462)

PMDD source page inventory (cumulative)

29 source pages with `condition: pmdd` now in wiki/sources/

Next intended work (priority order)

  1. PMDD disease entity page — now publishable (6 sources, threshold met); needs content expansion with all new sources; key additions: circadian layer, DM comorbidity, probiotics section, asthma/allergy risk factor, EFA intervention
  2. PMDD signature page — still stub at 6/10 sources; needs 4 more to reach threshold; consider building content from existing sources while accumulating more
  3. Fibromyalgia folder — ~58 PDFs, 7 source pages already; per ingest-priority-queue.md, next condition
  4. Cross-condition flag: quaranta-2019 connects PCOS/endometriosis/BV via FMT — consider creating or updating `wiki/interventions/fmt.md` with PCOS triangle evidence (animal model only)
  5. New concept page candidates: `wiki/concepts/gut-vagina-axis.md` (mentioned in 3+ sources without own page — Quaranta 2019, Fakruddin 2025, plus others)

Key anomalies to watch

  • PMDD PDF folder had ~40% misfiling rate — all resolved in this session
  • quaranta-2019 filed under condition: pcos (not pmdd) — relevant cross-condition but not PMDD-primary
  • yang-2023 food allergy → PMD finding is novel and not yet reflected in PMDD entity body content — add in next entity expansion
  • Fakruddin 2025 published October 2025 (Microbial Bioactives) — very recent; verify DOI resolution
  • itriyeva-2022 DOI resolves to doi.org/10.1016/j.cppeds.2022.101187 — verify before outreach